Not today Sir, Probably not tomorrow.............................................. bayfront arena st. pete '94
you're finally here and I'm a mess................................................... nationwide arena columbus '10
memories like fingerprints are slowly raising.................................... first niagara center buffalo '13
another man ..... moved by sleight of hand...................................... joe louis arena detroit '14
my counter-argument would be, if the unvaxxed hadnt greatly contributed to spread of delta, he and many others wouldnt have died when they did.....
He was suffering from cancer, so that's going to be a big part.
for his case specifically. virus overspread generally..... but even then how many folks you think are undergoing treatment for cancer? or other serious health issues. that A. are more susceptable to catching it then once diagnosed...... and B. how many beds are taken unnecessarily had some been more objective about covid and its implications.
fuck, all the kids with all kinds of different leukemias.
Not today Sir, Probably not tomorrow.............................................. bayfront arena st. pete '94
you're finally here and I'm a mess................................................... nationwide arena columbus '10
memories like fingerprints are slowly raising.................................... first niagara center buffalo '13
another man ..... moved by sleight of hand...................................... joe louis arena detroit '14
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brianlux
Moving through All Kinds of Terrain. Posts: 40,764
We are going through torture here too brian. Our kids are ill . Keep isolating then testing then waiting then back to school. Then repeat. Its a fucking horrendous way to exist. At this point we will get covid in the next weeks. Both schools have cases. Its pathetic here now. Just animals all thrown to the slaughter now. I hate this.
Oh man, Rob, I am sorry to hear it is so prevalent where you live. I hope none of your get that damn virus! Stay well.
Yes the uninformed idiots no doubt but the man was suffering from Cancer and his body couldn’t fight if any infection even though he was fully vaccinated!
"Uninformed" is the key word for the anti-vax crowd, for sure, as well as obstinate, and foolish.
**************************
I'm feeling better today, so probably just dealing with chronic fatigue, but I'm getting the COVID test today anyway to be sure.
“The fear of death follows from the fear of life. A man [or woman] who lives fully is prepared to die at any time.”
So if your fully vaccinated and every time you wake up feeling Ill you are getting tested? Really. I guess I’m in the minority, I trust the vaccine works and will keep me healthy. Why not just stay home. At some point in a society that is fully vaccinated we must move on with life.
Just like our idiot government needing a Covid test to get back into Canada if fully vaccinated…lmfao. I can go to the US and customs will do attestation and will do random checks where you have to prove vax status… once border is open.
of course this is what happens when you elect a trust fund baby as PM. The nimrod has 0 fucking common sense…
So if your fully vaccinated and every time you wake up feeling Ill you are getting tested? Really. I guess I’m in the minority, I trust the vaccine works and will keep me healthy. Why not just stay home. At some point in a society that is fully vaccinated we must move on with life.
Just like our idiot government needing a Covid test to get back into Canada if fully vaccinated…lmfao. I can go to the US and customs will do attestation and will do random checks where you have to prove vax status… once border is open.
of course this is what happens when you elect a trust fund baby as PM. The nimrod has 0 fucking common sense…
Are you saying the US will not need a mandatory test to fly into the country like they need now?
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brianlux
Moving through All Kinds of Terrain. Posts: 40,764
Got my COVID test today. Feeling pretty good so not as concerned about have the virus but glad to know I will know for sure in a couple days.
On the NOT GOOD side of things: On my way home, I unfortunately had to pass the courthouse on Main St. in Placerville here in Dumbfuck... I mean Hell Dorado County, California, and on both sides of the street were masses of anti-maskers waiving "no masks" signs and yelling about their freedumbs. There were a ton of indoctrinated (but probably not vaccinated) little kids among the crowd. I am told this was a "school walk out" to protest wearing masks. Way to go, anti-vax, anti-mask parents. Don't let your kids stay in school to become educated. Take them out on the streets with you so they can become as stupid as you are. These people heads and mine are in very dark places. My head space right now is a dark cloud of disgust. These protester's dark head space smells really foul for some reason. You get my drift.
“The fear of death follows from the fear of life. A man [or woman] who lives fully is prepared to die at any time.”
Got my COVID test today. Feeling pretty good so not as concerned about have the virus but glad to know I will know for sure in a couple days.
On the NOT GOOD side of things: On my way home, I unfortunately had to pass the courthouse on Main St. in Placerville here in Dumbfuck... I mean Hell Dorado County, California, and on both sides of the street were masses of anti-maskers waiving "no masks" signs and yelling about their freedumbs. There were a ton of indoctrinated (but probably not vaccinated) little kids among the crowd. I am told this was a "school walk out" to protest wearing masks. Way to go, anti-vax, anti-mask parents. Don't let your kids stay in school to become educated. Take them out on the streets with you so they can become as stupid as you are. These people heads and mine are in very dark places. My head space right now is a dark cloud of disgust. These protester's dark head space smells really foul for some reason. You get my drift.
just remember....these idiots have always walked among us. pre 2020, we had People Of Walmart. now we have anti maskers. I'm guessing there's lots of crossover of those two groups.
I just wish we could go back to just smacking our foreheads at their stupidity instead of depending on these morons to stop the pandemic.
Flight Risk out NOW!
www.headstonesband.com
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brianlux
Moving through All Kinds of Terrain. Posts: 40,764
Got my COVID test today. Feeling pretty good so not as concerned about have the virus but glad to know I will know for sure in a couple days.
On the NOT GOOD side of things: On my way home, I unfortunately had to pass the courthouse on Main St. in Placerville here in Dumbfuck... I mean Hell Dorado County, California, and on both sides of the street were masses of anti-maskers waiving "no masks" signs and yelling about their freedumbs. There were a ton of indoctrinated (but probably not vaccinated) little kids among the crowd. I am told this was a "school walk out" to protest wearing masks. Way to go, anti-vax, anti-mask parents. Don't let your kids stay in school to become educated. Take them out on the streets with you so they can become as stupid as you are. These people heads and mine are in very dark places. My head space right now is a dark cloud of disgust. These protester's dark head space smells really foul for some reason. You get my drift.
just remember....these idiots have always walked among us. pre 2020, we had People Of Walmart. now we have anti maskers. I'm guessing there's lots of crossover of those two groups.
I just wish we could go back to just smacking our foreheads at their stupidity instead of depending on these morons to stop the pandemic.
So true! It's one thing to be dumb, another to be dumb and dangerous. Exposing others- including kids who are too young to know better- is just wrong.
“The fear of death follows from the fear of life. A man [or woman] who lives fully is prepared to die at any time.”
Why COVID boosters weren't tweaked to better match variants
By LAURAN NEERGAARD
Today
More COVID-19 booster shots may be on the way -- but when it’s your turn, you’ll get an extra dose of the original vaccine, not one updated to better match the extra-contagious delta variant.
And that has some experts wondering if the booster campaign is a bit of a missed opportunity to target delta and its likely descendants.
“Don’t we want to match the new strains that are most likely to circulate as closely as possible?” Dr. Cody Meissner of Tufts Medical Center, an adviser to the Food and Drug Administration, challenged Pfizer scientists recently.
“I don't quite understand why this is not delta because that's what we're facing right now,” fellow adviser Dr. Patrick Moore of the University of Pittsburgh said last week as government experts debated whether it's time for Moderna boosters. He wondered if such a switch would be particularly useful to block mild infection.
The simple answer: The FDA last month OK'd extra doses of Pfizer’s original recipe after studies showed it still works well enough against delta -- and those doses could be rolled out right away. Now the FDA is weighing evidence for boosters of the original Moderna and Johnson & Johnson vaccines.
“It’s less churn and burn on the manufacturing” to only switch formulas when it’s really necessary, said FDA vaccine chief Dr. Peter Marks.
But Pfizer and Moderna are hedging their bets. They’re already testing experimental doses customized to delta and another variant, learning how to rapidly tweak the formula in case a change eventually is needed -- for today’s mutants or a brand new one. The tougher question for regulators is how they’d decide if and when to ever order such a switch.
What we know so far:
CURRENT VACCINES ARE WORKING EVEN AGAINST DELTA
Vaccines used in the U.S. remain strongly effective against hospitalization and death from COVID-19, even after the delta variant took over, but authorities hope to shore up waning protection against less severe infection and for high-risk populations. Studies show an extra dose of the original formulas revs up virus-fighting antibodies that fend off infection, including antibodies that target delta.
MIGHT A DELTA-SPECIFIC BOOSTER WORK EVEN BETTER?
Vaccines target the spike protein that coats the coronavirus. Mutations in that protein made delta more contagious but to the immune system, it doesn’t look all that different, said virus expert Richard Webby of St. Jude Children’s Research Hospital.
That means there’s no guarantee a delta-specific booster would protect any better, said University of Pennsylvania immunologist John Wherry. Waiting for studies to settle that question -- and if necessary, brewing updated doses -- would have delayed rolling out boosters to people deemed to need them now.
Still, because delta is now the dominant version of the virus worldwide it almost certainly will be a common ancestor for whatever evolves next in a mostly unvaccinated world, said Trevor Bedford, a biologist and genetics expert at the Fred Hutchinson Cancer Research Center.
A delta-updated vaccine would “help to provide a buffer against those additional mutations,” he said. Bedford is paid by the Howard Hughes Medical Institute, which also supports The Associated Press Health and Science Department.
TWEAKING THE RECIPE
The Pfizer and Moderna vaccines are made with a piece of genetic code called messenger RNA that tells the body to make harmless copies of the spike protein so it's trained to recognize the virus. Updating the formula merely requires swapping out the original genetic code with mRNA for a mutated spike protein.
Both companies first experimented with tweaked doses against a mutant that emerged in South Africa, the beta variant, that has been the most vaccine-resistant to date, more so than the delta variant. Lab tests showed the updated shots produced potent antibodies. But the beta variant didn’t spread widely.
Now the companies have studies underway of fully vaccinated people who agreed to test a booster dose tweaked to match delta. Moderna’s studies also include some shots that combine protection against more than one version of the coronavirus -- much like today’s flu vaccines work against multiple influenza strains.
The mRNA vaccines are considered the easiest kind to tweak but some other vaccine makers also are exploring how to change their recipes if necessary.
WHY STUDY UPDATED SHOTS IF THEY’RE NOT YET NEEDED?
Moderna's Dr. Jacqueline Miller told an FDA advisory panel last week the company is studying variant-specific boosters now to learn if they offer advantages, and to be ready if they're needed.
And Penn’s Wherry said it is critical to carefully analyze how the body reacts to updated shots because the immune system tends to “imprint” a stronger memory of the first virus strain it encounters. That raises questions about whether a subtly different booster would prompt a temporary jump in antibodies the body’s made before -- or the bigger goal, a broader and more durable response that might even be better positioned for the next mutations to come along.
NO RULES YET FOR MAKING A SWITCH
“What is the tripping point?” asked Webby, who is part of a World Health Organization network that tracks influenza evolution. “A lot of what is going to need to go into that decision making is just going to be learned by experience, unfortunately.”
Bedford said now is the time to decide what drop in vaccine effectiveness would trigger a formula change, just as is done with flu vaccines every year.
That’s important not just if a dramatically worse variant suddenly develops. Like many scientists, Bedford expects the coronavirus to eventually evolve from a global crisis into a regular threat every winter -- which might mean more regular boosters, maybe even yearly in combination with the flu shot.
Timing between shots matters, too, Wherry noted.
“Your boostability may actually improve with longer intervals between stimulation,” he said. While scientists have learned a lot about the coronavirus, “the story’s not finished yet and we don’t know what the last chapters say.”
___
The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content.
Not today Sir, Probably not tomorrow.............................................. bayfront arena st. pete '94
you're finally here and I'm a mess................................................... nationwide arena columbus '10
memories like fingerprints are slowly raising.................................... first niagara center buffalo '13
another man ..... moved by sleight of hand...................................... joe louis arena detroit '14
Nick Rolovich fired as Wash State head coach for refusing to vax. He was the highest paid employee in the state.
As an Alum, very happy the Qanon moron is gone. The highest paid state employee at a research institution should not be an anti science conspiracy theory believing nut job.
Nick Rolovich fired as Wash State head coach for refusing to vax. He was the highest paid employee in the state.
As an Alum, very happy the Qanon moron is gone. The highest paid state employee at a research institution should not be an anti science conspiracy theory believing nut job.
Let us know when-if ya get the A-ok. My kid passed her day 8 Canada re-entry test and is finished her 14 day quarantine-restrictions ie: no school😊 Thanks kiddo for your Ohana sacrifice!
Good news here for concert-goers and musicians. Only 6 weeks behind former projections that didn't have delta considered, so not too shabby.
Let us know when-if ya get the A-ok. My kid passed her day 8 Canada re-entry test and is finished her 14 day quarantine-restrictions ie: no school😊 Thanks kiddo for your Ohana sacrifice!
Good news here for concert-goers and musicians. Only 6 weeks behind former projections that didn't have delta considered, so not too shabby.
I'm going to my first concert in ages on Friday! Very excited.
'05 - TO, '06 - TO 1, '08 - NYC 1 & 2, '09 - TO, Chi 1 & 2, '10 - Buffalo, NYC 1 & 2, '11 - TO 1 & 2, Hamilton, '13 - Buffalo, Brooklyn 1 & 2, '15 - Global Citizen, '16 - TO 1 & 2, Chi 2
EV
Toronto Film Festival 9/11/2007, '08 - Toronto 1 & 2, '09 - Albany 1, '11 - Chicago 1
^ Party on Benjs!I missed the excitement of looking forward to Ohana because of the trepidation of testing negative and not be allowed to fly to the States. Of course, next month I will the option to drive.
Good for you. What show you going to?
It'll be a celebration when BC gets music back in stadiums!
^ Party on Benjs!I missed the excitement of looking forward to Ohana because of the trepidation of testing negative and not be allowed to fly to the States. Of course, next month I will the option to drive.
Good for you. What show you going to?
It'll be a celebration when BC gets music back in stadiums!
I hear ya. It's a Feist concert, in the round, backstage at the Hummingbird Centre in Toronto, with around 200 people total. I'm very excited
On the stadiums - I'll admit, I feel much more anxiety about big crowds than I did a year and a half ago.
'05 - TO, '06 - TO 1, '08 - NYC 1 & 2, '09 - TO, Chi 1 & 2, '10 - Buffalo, NYC 1 & 2, '11 - TO 1 & 2, Hamilton, '13 - Buffalo, Brooklyn 1 & 2, '15 - Global Citizen, '16 - TO 1 & 2, Chi 2
EV
Toronto Film Festival 9/11/2007, '08 - Toronto 1 & 2, '09 - Albany 1, '11 - Chicago 1
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mickeyrat
up my ass, like Chadwick was up his Posts: 35,914
Fox News' Cavuto tests positive for COVID-19, urges vaccines
2 hours ago
LOS ANGELES (AP) — Fox News Channel anchor Neil Cavuto tested positive for COVID-19, which he said was surprising but made him grateful that he was vaccinated.
Cavuto, who learned of the test results after Monday's episode of “Your World with Neil Cavuto,” wasn't on the air Tuesday.
“While I’m somewhat stunned by this news, doctors tell me I’m lucky as well. Had I not been vaccinated, and with all my medical issues, this would be a far more dire situation,” Cavuto said in a statement released by Fox News.
“It’s not, because I did and I’m surviving this because I did. I hope anyone and everyone gets that message loud and clear. Get vaccinated, for yourself and everyone around you,” the journalist said.
Cavuto, who had open-heart surgery in 2016 and was treated for cancer in the 1980s, was diagnosed with multiple sclerosis in 1997.
Also Tuesday, CNN's John King revealed on his “Inside Politics” show that he has multiple sclerosis, which makes him immunocompromised. “So, I’m grateful you’re all vaccinated,” he said during a panel discussion. CNN mandates that all of its employees who work in an office or in the field with other people be vaccinated.
Fox News employees are required to let the company know their vaccination status and, if they haven’t been vaccinated, to be tested regularly for COVID-19.
Cavuto also anchors Fox News Channel's “Cavuto Live” on Saturdays and Fox Business Network's weekday show “Cavuto: Coast to Coast.”
Not today Sir, Probably not tomorrow.............................................. bayfront arena st. pete '94
you're finally here and I'm a mess................................................... nationwide arena columbus '10
memories like fingerprints are slowly raising.................................... first niagara center buffalo '13
another man ..... moved by sleight of hand...................................... joe louis arena detroit '14
Let us know when-if ya get the A-ok. My kid passed her day 8 Canada re-entry test and is finished her 14 day quarantine-restrictions ie: no school😊 Thanks kiddo for your Ohana sacrifice!
Good news here for concert-goers and musicians. Only 6 weeks behind former projections that didn't have delta considered, so not too shabby.
I'm going to my first concert on Saturday. Old School Canadian punk band play a small bar a reduced capacity. 75 people.
I've also been going to movies and enjoying the way they spaced out the seats. (and empty seat between groups kind of thing).
I wonder how hard it's going to be to adjust to everything going back wide open.
I also wonder why our government isn't talking about booster. I think the majority of people got Pfizer so people vaccinate earlier are hitting or going past 6 months now. Their halfassed rolling out boosters to care homes, but it seems odd they haven't started to warm up a booster shot program yet.
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brianlux
Moving through All Kinds of Terrain. Posts: 40,764
Thanks, Tish. Should know in a day or two.
Hey concert goers, be safe. And for crying out loud, have a great time!
“The fear of death follows from the fear of life. A man [or woman] who lives fully is prepared to die at any time.”
Variously credited to Mark Twain or Edward Abbey.
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mickeyrat
up my ass, like Chadwick was up his Posts: 35,914
Let us know when-if ya get the A-ok. My kid passed her day 8 Canada re-entry test and is finished her 14 day quarantine-restrictions ie: no school😊 Thanks kiddo for your Ohana sacrifice!
Good news here for concert-goers and musicians. Only 6 weeks behind former projections that didn't have delta considered, so not too shabby.
I'm going to my first concert on Saturday. Old School Canadian punk band play a small bar a reduced capacity. 75 people.
I've also been going to movies and enjoying the way they spaced out the seats. (and empty seat between groups kind of thing).
I wonder how hard it's going to be to adjust to everything going back wide open.
I also wonder why our government isn't talking about booster. I think the majority of people got Pfizer so people vaccinate earlier are hitting or going past 6 months now. Their halfassed rolling out boosters to care homes, but it seems odd they haven't started to warm up a booster shot program yet.
didnt canada increase the time between doses? with suggestion it was more effective?
Not today Sir, Probably not tomorrow.............................................. bayfront arena st. pete '94
you're finally here and I'm a mess................................................... nationwide arena columbus '10
memories like fingerprints are slowly raising.................................... first niagara center buffalo '13
another man ..... moved by sleight of hand...................................... joe louis arena detroit '14
Let us know when-if ya get the A-ok. My kid passed her day 8 Canada re-entry test and is finished her 14 day quarantine-restrictions ie: no school😊 Thanks kiddo for your Ohana sacrifice!
Good news here for concert-goers and musicians. Only 6 weeks behind former projections that didn't have delta considered, so not too shabby.
I'm going to my first concert on Saturday. Old School Canadian punk band play a small bar a reduced capacity. 75 people.
I've also been going to movies and enjoying the way they spaced out the seats. (and empty seat between groups kind of thing).
I wonder how hard it's going to be to adjust to everything going back wide open.
I also wonder why our government isn't talking about booster. I think the majority of people got Pfizer so people vaccinate earlier are hitting or going past 6 months now. Their halfassed rolling out boosters to care homes, but it seems odd they haven't started to warm up a booster shot program yet.
Insufficient evidence so far that the average adult needs a booster yet.
my small self... like a book amongst the many on a shelf
Let us know when-if ya get the A-ok. My kid passed her day 8 Canada re-entry test and is finished her 14 day quarantine-restrictions ie: no school😊 Thanks kiddo for your Ohana sacrifice!
Good news here for concert-goers and musicians. Only 6 weeks behind former projections that didn't have delta considered, so not too shabby.
I'm going to my first concert on Saturday. Old School Canadian punk band play a small bar a reduced capacity. 75 people.
I've also been going to movies and enjoying the way they spaced out the seats. (and empty seat between groups kind of thing).
I wonder how hard it's going to be to adjust to everything going back wide open.
I also wonder why our government isn't talking about booster. I think the majority of people got Pfizer so people vaccinate earlier are hitting or going past 6 months now. Their halfassed rolling out boosters to care homes, but it seems odd they haven't started to warm up a booster shot program yet.
didnt canada increase the time between doses? with suggestion it was more effective?
Yes, we have good data now that demonstrates improved protection when the first and second doses were spaced out further, between 12-16 weeks
my small self... like a book amongst the many on a shelf
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mickeyrat
up my ass, like Chadwick was up his Posts: 35,914
Let us know when-if ya get the A-ok. My kid passed her day 8 Canada re-entry test and is finished her 14 day quarantine-restrictions ie: no school😊 Thanks kiddo for your Ohana sacrifice!
Good news here for concert-goers and musicians. Only 6 weeks behind former projections that didn't have delta considered, so not too shabby.
I'm going to my first concert on Saturday. Old School Canadian punk band play a small bar a reduced capacity. 75 people.
I've also been going to movies and enjoying the way they spaced out the seats. (and empty seat between groups kind of thing).
I wonder how hard it's going to be to adjust to everything going back wide open.
I also wonder why our government isn't talking about booster. I think the majority of people got Pfizer so people vaccinate earlier are hitting or going past 6 months now. Their halfassed rolling out boosters to care homes, but it seems odd they haven't started to warm up a booster shot program yet.
didnt canada increase the time between doses? with suggestion it was more effective?
Yes, we have good data now that demonstrates improved protection when the first and second doses were spaced out further, between 12-16 weeks
and would further bolster arguments for boosters in general. Timing in the Canadian model is the question....
Not today Sir, Probably not tomorrow.............................................. bayfront arena st. pete '94
you're finally here and I'm a mess................................................... nationwide arena columbus '10
memories like fingerprints are slowly raising.................................... first niagara center buffalo '13
another man ..... moved by sleight of hand...................................... joe louis arena detroit '14
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mickeyrat
up my ass, like Chadwick was up his Posts: 35,914
I would be or am eligible based on when I received second shot.
Consulting with my PCP, she/we determined it isnt needed at this time based on my general day to day activities coupled with keeping ample availability for the folks yet to pull their heads out of their asses and stop the excuses.
Not today Sir, Probably not tomorrow.............................................. bayfront arena st. pete '94
you're finally here and I'm a mess................................................... nationwide arena columbus '10
memories like fingerprints are slowly raising.................................... first niagara center buffalo '13
another man ..... moved by sleight of hand...................................... joe louis arena detroit '14
Let us know when-if ya get the A-ok. My kid passed her day 8 Canada re-entry test and is finished her 14 day quarantine-restrictions ie: no school😊 Thanks kiddo for your Ohana sacrifice!
Good news here for concert-goers and musicians. Only 6 weeks behind former projections that didn't have delta considered, so not too shabby.
I'm going to my first concert on Saturday. Old School Canadian punk band play a small bar a reduced capacity. 75 people.
I've also been going to movies and enjoying the way they spaced out the seats. (and empty seat between groups kind of thing).
I wonder how hard it's going to be to adjust to everything going back wide open.
I also wonder why our government isn't talking about booster. I think the majority of people got Pfizer so people vaccinate earlier are hitting or going past 6 months now. Their halfassed rolling out boosters to care homes, but it seems odd they haven't started to warm up a booster shot program yet.
didnt canada increase the time between doses? with suggestion it was more effective?
Yes, we have good data now that demonstrates improved protection when the first and second doses were spaced out further, between 12-16 weeks
and would further bolster arguments for boosters in general. Timing in the Canadian model is the question....
Our model varied. It was based in supply not on science (as to be honest I don't think a lot of science was available on spacing). My doses were 8 weeks and a few days apart. I think for people getting vaxxed now, opposed to being in the queue, have a shorter interval.
Comments
my counter-argument would be, if the unvaxxed hadnt greatly contributed to spread of delta, he and many others wouldnt have died when they did.....
Not today Sir, Probably not tomorrow.............................................. bayfront arena st. pete '94
you're finally here and I'm a mess................................................... nationwide arena columbus '10
memories like fingerprints are slowly raising.................................... first niagara center buffalo '13
another man ..... moved by sleight of hand...................................... joe louis arena detroit '14
1998: Noblesville; 2003: Noblesville; 2009: EV Nashville, Chicago, Chicago
2010: St Louis, Columbus, Noblesville; 2011: EV Chicago, East Troy, East Troy
2013: London ON, Chicago; 2014: Cincy, St Louis, Moline (NO CODE)
2016: Lexington, Wrigley #1; 2018: Wrigley, Wrigley, Boston, Boston
2020: Oakland, Oakland: 2021: EV Ohana, Ohana, Ohana, Ohana
2022: Oakland, Oakland, Nashville, Louisville; 2023: Chicago, Chicago, Noblesville
2024: Noblesville, Wrigley, Wrigley, Ohana, Ohana
Not today Sir, Probably not tomorrow.............................................. bayfront arena st. pete '94
you're finally here and I'm a mess................................................... nationwide arena columbus '10
memories like fingerprints are slowly raising.................................... first niagara center buffalo '13
another man ..... moved by sleight of hand...................................... joe louis arena detroit '14
So if your fully vaccinated and every time you wake up feeling Ill you are getting tested? Really. I guess I’m in the minority, I trust the vaccine works and will keep me healthy. Why not just stay home. At some point in a society that is fully vaccinated we must move on with life.
of course this is what happens when you elect a trust fund baby as PM. The nimrod has 0 fucking common sense…
These people heads and mine are in very dark places. My head space right now is a dark cloud of disgust. These protester's dark head space smells really foul for some reason. You get my drift.
I just wish we could go back to just smacking our foreheads at their stupidity instead of depending on these morons to stop the pandemic.
www.headstonesband.com
More COVID-19 booster shots may be on the way -- but when it’s your turn, you’ll get an extra dose of the original vaccine, not one updated to better match the extra-contagious delta variant.
And that has some experts wondering if the booster campaign is a bit of a missed opportunity to target delta and its likely descendants.
“Don’t we want to match the new strains that are most likely to circulate as closely as possible?” Dr. Cody Meissner of Tufts Medical Center, an adviser to the Food and Drug Administration, challenged Pfizer scientists recently.
“I don't quite understand why this is not delta because that's what we're facing right now,” fellow adviser Dr. Patrick Moore of the University of Pittsburgh said last week as government experts debated whether it's time for Moderna boosters. He wondered if such a switch would be particularly useful to block mild infection.
The simple answer: The FDA last month OK'd extra doses of Pfizer’s original recipe after studies showed it still works well enough against delta -- and those doses could be rolled out right away. Now the FDA is weighing evidence for boosters of the original Moderna and Johnson & Johnson vaccines.
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They were some of 9/11's biggest names. Where are they now?
“It’s less churn and burn on the manufacturing” to only switch formulas when it’s really necessary, said FDA vaccine chief Dr. Peter Marks.
But Pfizer and Moderna are hedging their bets. They’re already testing experimental doses customized to delta and another variant, learning how to rapidly tweak the formula in case a change eventually is needed -- for today’s mutants or a brand new one. The tougher question for regulators is how they’d decide if and when to ever order such a switch.
What we know so far:
CURRENT VACCINES ARE WORKING EVEN AGAINST DELTA
Vaccines used in the U.S. remain strongly effective against hospitalization and death from COVID-19, even after the delta variant took over, but authorities hope to shore up waning protection against less severe infection and for high-risk populations. Studies show an extra dose of the original formulas revs up virus-fighting antibodies that fend off infection, including antibodies that target delta.
MIGHT A DELTA-SPECIFIC BOOSTER WORK EVEN BETTER?
Vaccines target the spike protein that coats the coronavirus. Mutations in that protein made delta more contagious but to the immune system, it doesn’t look all that different, said virus expert Richard Webby of St. Jude Children’s Research Hospital.
That means there’s no guarantee a delta-specific booster would protect any better, said University of Pennsylvania immunologist John Wherry. Waiting for studies to settle that question -- and if necessary, brewing updated doses -- would have delayed rolling out boosters to people deemed to need them now.
Still, because delta is now the dominant version of the virus worldwide it almost certainly will be a common ancestor for whatever evolves next in a mostly unvaccinated world, said Trevor Bedford, a biologist and genetics expert at the Fred Hutchinson Cancer Research Center.
A delta-updated vaccine would “help to provide a buffer against those additional mutations,” he said. Bedford is paid by the Howard Hughes Medical Institute, which also supports The Associated Press Health and Science Department.
TWEAKING THE RECIPE
The Pfizer and Moderna vaccines are made with a piece of genetic code called messenger RNA that tells the body to make harmless copies of the spike protein so it's trained to recognize the virus. Updating the formula merely requires swapping out the original genetic code with mRNA for a mutated spike protein.
Both companies first experimented with tweaked doses against a mutant that emerged in South Africa, the beta variant, that has been the most vaccine-resistant to date, more so than the delta variant. Lab tests showed the updated shots produced potent antibodies. But the beta variant didn’t spread widely.
Now the companies have studies underway of fully vaccinated people who agreed to test a booster dose tweaked to match delta. Moderna’s studies also include some shots that combine protection against more than one version of the coronavirus -- much like today’s flu vaccines work against multiple influenza strains.
The mRNA vaccines are considered the easiest kind to tweak but some other vaccine makers also are exploring how to change their recipes if necessary.
WHY STUDY UPDATED SHOTS IF THEY’RE NOT YET NEEDED?
Moderna's Dr. Jacqueline Miller told an FDA advisory panel last week the company is studying variant-specific boosters now to learn if they offer advantages, and to be ready if they're needed.
And Penn’s Wherry said it is critical to carefully analyze how the body reacts to updated shots because the immune system tends to “imprint” a stronger memory of the first virus strain it encounters. That raises questions about whether a subtly different booster would prompt a temporary jump in antibodies the body’s made before -- or the bigger goal, a broader and more durable response that might even be better positioned for the next mutations to come along.
NO RULES YET FOR MAKING A SWITCH
“What is the tripping point?” asked Webby, who is part of a World Health Organization network that tracks influenza evolution. “A lot of what is going to need to go into that decision making is just going to be learned by experience, unfortunately.”
Bedford said now is the time to decide what drop in vaccine effectiveness would trigger a formula change, just as is done with flu vaccines every year.
That’s important not just if a dramatically worse variant suddenly develops. Like many scientists, Bedford expects the coronavirus to eventually evolve from a global crisis into a regular threat every winter -- which might mean more regular boosters, maybe even yearly in combination with the flu shot.
Timing between shots matters, too, Wherry noted.
“Your boostability may actually improve with longer intervals between stimulation,” he said. While scientists have learned a lot about the coronavirus, “the story’s not finished yet and we don’t know what the last chapters say.”
___
The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content.
Not today Sir, Probably not tomorrow.............................................. bayfront arena st. pete '94
you're finally here and I'm a mess................................................... nationwide arena columbus '10
memories like fingerprints are slowly raising.................................... first niagara center buffalo '13
another man ..... moved by sleight of hand...................................... joe louis arena detroit '14
As an Alum, very happy the Qanon moron is gone. The highest paid state employee at a research institution should not be an anti science conspiracy theory believing nut job.
www.cluthelee.com
www.cluthe.com
Let us know when-if ya get the A-ok. My kid passed her day 8 Canada re-entry test and is finished her 14 day quarantine-restrictions ie: no school😊 Thanks kiddo for your Ohana sacrifice!
Good news here for concert-goers and musicians. Only 6 weeks behind former projections that didn't have delta considered, so not too shabby.
EV
Toronto Film Festival 9/11/2007, '08 - Toronto 1 & 2, '09 - Albany 1, '11 - Chicago 1
Good for you. What show you going to?
It'll be a celebration when BC gets music back in stadiums!
On the stadiums - I'll admit, I feel much more anxiety about big crowds than I did a year and a half ago.
EV
Toronto Film Festival 9/11/2007, '08 - Toronto 1 & 2, '09 - Albany 1, '11 - Chicago 1
LOS ANGELES (AP) — Fox News Channel anchor Neil Cavuto tested positive for COVID-19, which he said was surprising but made him grateful that he was vaccinated.
Cavuto, who learned of the test results after Monday's episode of “Your World with Neil Cavuto,” wasn't on the air Tuesday.
“While I’m somewhat stunned by this news, doctors tell me I’m lucky as well. Had I not been vaccinated, and with all my medical issues, this would be a far more dire situation,” Cavuto said in a statement released by Fox News.
“It’s not, because I did and I’m surviving this because I did. I hope anyone and everyone gets that message loud and clear. Get vaccinated, for yourself and everyone around you,” the journalist said.
Cavuto, who had open-heart surgery in 2016 and was treated for cancer in the 1980s, was diagnosed with multiple sclerosis in 1997.
Also Tuesday, CNN's John King revealed on his “Inside Politics” show that he has multiple sclerosis, which makes him immunocompromised. “So, I’m grateful you’re all vaccinated,” he said during a panel discussion. CNN mandates that all of its employees who work in an office or in the field with other people be vaccinated.
CORONAVIRUS PANDEMIC
COVID-19 and pregnancy: Women regret not getting the vaccine
As deaths rise, Russian doctors despair at low vaccine rate
US expected to authorize mix-and-match COVID booster shots
US Homeland Security secretary tests positive for COVID
Fox News employees are required to let the company know their vaccination status and, if they haven’t been vaccinated, to be tested regularly for COVID-19.
Cavuto also anchors Fox News Channel's “Cavuto Live” on Saturdays and Fox Business Network's weekday show “Cavuto: Coast to Coast.”
Not today Sir, Probably not tomorrow.............................................. bayfront arena st. pete '94
you're finally here and I'm a mess................................................... nationwide arena columbus '10
memories like fingerprints are slowly raising.................................... first niagara center buffalo '13
another man ..... moved by sleight of hand...................................... joe louis arena detroit '14
didnt canada increase the time between doses? with suggestion it was more effective?
Not today Sir, Probably not tomorrow.............................................. bayfront arena st. pete '94
you're finally here and I'm a mess................................................... nationwide arena columbus '10
memories like fingerprints are slowly raising.................................... first niagara center buffalo '13
another man ..... moved by sleight of hand...................................... joe louis arena detroit '14
and would further bolster arguments for boosters in general. Timing in the Canadian model is the question....
Not today Sir, Probably not tomorrow.............................................. bayfront arena st. pete '94
you're finally here and I'm a mess................................................... nationwide arena columbus '10
memories like fingerprints are slowly raising.................................... first niagara center buffalo '13
another man ..... moved by sleight of hand...................................... joe louis arena detroit '14
Not today Sir, Probably not tomorrow.............................................. bayfront arena st. pete '94
you're finally here and I'm a mess................................................... nationwide arena columbus '10
memories like fingerprints are slowly raising.................................... first niagara center buffalo '13
another man ..... moved by sleight of hand...................................... joe louis arena detroit '14
Our model varied. It was based in supply not on science (as to be honest I don't think a lot of science was available on spacing). My doses were 8 weeks and a few days apart. I think for people getting vaxxed now, opposed to being in the queue, have a shorter interval.