The coronavirus

cutz

https://twitter.com/JoelEmbiid/status/1246480282955513858?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed&ref_url=https%3A%2F%2Fcommunity.pearljam.com%2Fdiscussion%2F283837%2Fthe-coronavirus%2Fp166

cincybearcat

hedonist said:

This has been going around my head lately...

Regardless of what "leaders" mandate for a particular state, city, country, what have you...is it not considered prudent to avoid gatherings in pubs or similar spaces without being told to do so?  Doesn't common sense dictate basic safety measures for yourself, family and friends?

The mindset of some - "well, we haven't been TOLD we need to do X, Y & Z, so I'm taking advantage!" - strikes me as flouting reality for selfish reasons.  Just avoid that shit, for fuck's sake.

Yes. And the people that annoy me are the most are my Facebook friends that the day before their state started some restrictions were 1) at disney world 2) out at heir kids play....

this was after the nba/NCAA/concerts had been cancelled. But because no government directive they did what they wanted. And now they bitch about other people being out and about. 

cincybearcat

Spiritual_Chaos said:

hedonist said:

This has been going around my head lately...

Regardless of what "leaders" mandate for a particular state, city, country, what have you...is it not considered prudent to avoid gatherings in pubs or similar spaces without being told to do so?  Doesn't common sense dictate basic safety measures for yourself, family and friends?

The mindset of some - "well, we haven't been TOLD we need to do X, Y & Z, so I'm taking advantage!" - strikes me as flouting reality for selfish reasons.  Just avoid that shit, for fuck's sake.

So how long can a country stay on total lockdown? 

Sweden's public health authorities opinion about that is "for a limited amount of time", so they do not want to lockdown more than needed until it, according to them, is needed. And instead ask the population to adhere to their recommendations regarding hygiene and social distancing and people over 70 and in a risk group to be cautious etc. So that the health care can cope with it, and focus being on everyone in a riskgroup being protected. 

I use common sense regarding this every day. Even when visiting the half-empty local pub supporting it, sitting in a corner with two of my friends - neither being in a risk group or old. Not like I was Joe Biden every girl in the place. Or not washing my hands when I got home. Locking yourself up in a room, not meeting your family or anyone and eating all the toilet paper your have bunkered up last time you dared to leave your room because someone somehow could carry Corona like THE THING isn't all that feasible for everyone either. And for how long?

How long will a total lockdown work, before people start breaking it just because it turns into the new, boring, not feasible normal? And how much will have crashed because of it?

A vaccin won't come for at least 18 months.

I wish we could bet on this, if this continues to do this much harm to people and the economy... there is no way it will be 18 months. It will be streamlined some for sure. Taking some risks to move faster.

Spiritual_Chaos

Better than the swedish kings adress:

https://youtu.be/9yMxEY2lGcg

Spiritual_Chaos

Spiritual_Chaos

Scary, and a big failure, that the virus is spreading through retirement homes right now. 

Spiritual_Chaos

https://twitter.com/cspan/status/1246854614584082439?s=20

Spiritual_Chaos

https://twitter.com/natashaldaly/status/1246900371706036228?s=20

myoung321

Former New Orleans Saints kicker Tom Dempsey died Saturday due to complications from the Covid-19 . He was 73.

For decades, Dempsey was known for making one of the most famous kicks in NFL history. With the Saints trailing the Detroit Lions by two points — and just two seconds remaining in the game — Dempsey lined up for a then-record 63-yard field-goal attempt.

https://www.yahoo.com/sports/legendary-nfl-kicker-tom-dempsey-dies-after-fight-with-coronavirus-134917908.html

Renfield

Spiritual_Chaos said:

https://twitter.com/natashaldaly/status/1246900371706036228?s=20

This takes it to a whole new level of being scared

https://www.cbs42.com/news/national/tiger-at-bronx-zoo-tests-positive-for-covid-19/

YAKIMATSU

Renfield said:

Spiritual_Chaos said:

https://twitter.com/natashaldaly/status/1246900371706036228?s=20

This takes it to a whole new level of being scared

https://www.cbs42.com/news/national/tiger-at-bronx-zoo-tests-positive-for-covid-19/

If all animals are potentially carriers, words fail. 

mickeyrat

Renfield said:

Spiritual_Chaos said:

https://twitter.com/natashaldaly/status/1246900371706036228?s=20

This takes it to a whole new level of being scared

https://www.cbs42.com/news/national/tiger-at-bronx-zoo-tests-positive-for-covid-19/

article I read in other big cats were sick too but hadnt been tested...

Spiritual_Chaos

pjl44

Seems to be unique to cats

https://www.nature.com/articles/d41586-020-00984-8

Renfield

mickeyrat said:

Renfield said:

Spiritual_Chaos said:

https://twitter.com/natashaldaly/status/1246900371706036228?s=20

This takes it to a whole new level of being scared

https://www.cbs42.com/news/national/tiger-at-bronx-zoo-tests-positive-for-covid-19/

article I read in other big cats were sick too but hadnt been tested...

My friend in the Netherlands just told me a cat was diagnosed w Coronavirus in Belgium last week. Strange after 4 months.... I hope it’s not going to be an issue

Spunkie

Here's some info from my neck of the woods: https://news.ubc.ca/2020/04/02/ubc-led-study-finds-trial-drug-can-significantly-block-early-stages-of-covid-19-in-engineered-human-tissues/

Trial drug can significantly block early stages of COVID-19 in engineered human tissues

SCIENCE, HEALTH & TECHNOLOGY

Apr 2, 2020    |   For more information, contact Thandi Fletcher

‘There is hope for this horrible pandemic,’ says UBC scientist Dr. Josef Penninger

An international team led by University of British Columbia researcher Dr. Josef Penninger has found a trial drug that effectively blocks the cellular door SARS-CoV-2 uses to infect its hosts.

The findings, published today in Cell, hold promise as a treatment capable of stopping early infection of the novel coronavirus that, as of April 2, has affected more than 981,000 people and claimed the lives of 50,000 people worldwide.

The study provides new insights into key aspects of SARS-CoV-2, the virus that causes COVID-19, and its interactions on a cellular level, as well as how the virus can infect blood vessels and kidneys.

“We are hopeful our results have implications for the development of a novel drug for the treatment of this unprecedented pandemic,” says Penninger, professor in UBC’s faculty of medicine, director of the Life Sciences Institute and the Canada 150 Research Chair in Functional Genetics at UBC.

“This work stems from an amazing collaboration among academic researchers and companies, including Dr. Ryan Conder’s gastrointestinal group at STEMCELL Technologiesin Vancouver, Nuria Montserrat in Spain, Drs. Haibo Zhang and Art Slutsky from Toronto and especially Ali Mirazimi’s infectious biology team in Sweden, who have been working tirelessly day and night for weeks to better understand the pathology of this disease and to provide breakthrough therapeutic options.”

ACE2 — a protein on the surface of the cell membrane — is now at centre-stage in this outbreak as the key receptor for the spike glycoprotein of SARS-CoV-2. In earlier work, Penninger and colleagues at the University of Toronto and the Institute of Molecular Biology in Vienna first identified ACE2, and found that in living organisms, ACE2 is the key receptor for SARS, the viral respiratory illness recognized as a global threat in 2003. His laboratory also went on to link the protein to both cardiovascular disease and lung failure.

While the COVID-19 outbreak continues to spread around the globe, the absence of a clinically proven antiviral therapy or a treatment specifically targeting the critical SARS-CoV-2 receptor ACE2 on a molecular level has meant an empty arsenal for health care providers struggling to treat severe cases of COVID-19.

“Our new study provides very much needed direct evidence that a drug — called APN01 (human recombinant soluble angiotensin-converting enzyme 2 – hrsACE2) — soon to be tested in clinical trials by the European biotech company Apeiron Biologics, is useful as an antiviral therapy for COVID-19,” says Dr. Art Slutsky, a scientist at the Keenan Research Centre for Biomedical Science of St. Michael’s Hospital and professor at the University of Toronto who is a collaborator on the study.

In cell cultures analyzed in the current study, hrsACE2 inhibited the coronavirus load by a factor of 1,000-5,000. In engineered replicas of human blood vessel and kidneys — organoids grown from human stem cells — the researchers demonstrated that the virus can directly infect and duplicate itself in these tissues. This provides important information on the development of the disease and the fact that severe cases of COVID-19 present with multi-organ failure and evidence of cardiovascular damage. Clinical grade hrsACE2 also reduced the SARS-CoV-2 infection in these engineered human tissues.

“Using organoids allows us to test in a very agile way treatments that are already being used for other diseases, or that are close to being validated. In these moments in which time is short, human organoids save the time that we would spend to test a new drug in the human setting,” says Núria Montserrat, ICREA professor at the Institute for Bioengineering of Catalonia in Spain.

“The virus causing COVID-19 is a close sibling to the first SARS virus,” adds Penninger. “Our previous work has helped to rapidly identify ACE2 as the entry gate for SARS-CoV-2, which explains a lot about the disease. Now we know that a soluble form of ACE2 that catches the virus away, could be indeed a very rational therapy that specifically targets the gate the virus must take to infect us. There is hope for this horrible pandemic.”

This research was supported in part by the Canadian federal government through emergency funding focused on accelerating the development, testing, and implementation of measures to deal with the COVID-19 outbreak.

nicknyr15

https://nypost.com/2020/04/05/trump-admin-weighs-legal-action-over-alleged-chinese-hoarding-of-ppe/

Two of my vendors told me this in January. One of them being Ace. They told me all the n95 masks were being held in China. At the time I though they were giving me some corporate, by the book response for not having stock. 

Renfield

nicknyr15 said:

https://nypost.com/2020/04/05/trump-admin-weighs-legal-action-over-alleged-chinese-hoarding-of-ppe/

Two of my vendors told me this in January. One of them being Ace. They told me all the n95 masks were being held in China. At the time I though they were giving me some corporate, by the book response for not having stock. 

And what about Trump taking N95 masks away from Canada? 

nicknyr15

Renfield said:

nicknyr15 said:

https://nypost.com/2020/04/05/trump-admin-weighs-legal-action-over-alleged-chinese-hoarding-of-ppe/

Two of my vendors told me this in January. One of them being Ace. They told me all the n95 masks were being held in China. At the time I though they were giving me some corporate, by the book response for not having stock. 

And what about Trump taking N95 masks away from Canada? 

What does that have to what I posted? I’m talking about China 

Renfield

nicknyr15 said:

Renfield said:

nicknyr15 said:

https://nypost.com/2020/04/05/trump-admin-weighs-legal-action-over-alleged-chinese-hoarding-of-ppe/

Two of my vendors told me this in January. One of them being Ace. They told me all the n95 masks were being held in China. At the time I though they were giving me some corporate, by the book response for not having stock. 

And what about Trump taking N95 masks away from Canada? 

What does that have to what I posted? I’m talking about China 

It has a lot to do with what you posted.
I’m talking about the nerve of Trump thinking about suing China for hoarding PPE, but it’s ok for him to try to take away PPE designated for other counties.