Viruses / Vaccines
Comments
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Were those Texas democrats who caught the virus all vaccinated?It’s sad that I have to even type this but I’m legitimately asking, not instigating or trying to prove any point.0
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Strange, according to Statnews, who did a whole story on the beginnings of MRNA, it was developed by a Hungarian scientist named Katalin Kariko, who made the key breakthroughs. To be sure others were involved but this Dr. Malone isn't mentioned. Moderna and BioNTech took the work to the next level with substantial funding from PEs and the like. But again, looking at Dr. Malone's resume on Linked, he didn't work at any of these places. So it's curious how he 'invented' MRNA.gvn2fly1421 said:A recent series of tweets from Dr. Robert Malone, the "Inventor of mRNA vaccines and RNA as a drug". Interesting take. And best I can tell, he has stated he has been fully vaccinated.
Regardless, he doesn't have any special access to data or anything today, so not sure why you would consider him more of an expert on social health policies than the other immunologists, virologists, or other experts who recommend the opposite.
https://www.statnews.com/2020/11/10/the-story-of-mrna-how-a-once-dismissed-idea-became-a-leading-technology-in-the-covid-vaccine-race/
and then there's this.. https://www.logically.ai/factchecks/library/3aa2eefdUPDATE: Malone reached out to Logically, stating that he did not invent the mRNA vaccines, but instead the "vaccine technology platform." He also presented us with copies of nine patents – none of which showed that he invented the mRNA vaccines. The judgment for the claim has not changed.
The COVID-19 pandemic has given rise to a lot of potentially dangerous misinformation. For reliable advice on COVID-19, including symptoms, prevention, and available treatment, please refer to the World Health Organization or your national healthcare authority.
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Weird then that he is still parading himself on twitter that way and his website still claims that. Regardless, I think his points are pretty spot on.
https://www.rwmalonemd.com/mrna-vaccine-inventorIT ALL STARTED WHEN…
Dr. Malone is the inventor of mRNA vaccines (and DNA vaccines). He also discovered lipid mediated and naked RNA transfection technologies.
It all started when he was at the Salk Institute in 1987 and 1988. There, he pioneered in-vitro RNA transfection and also in-vivo RNA transfection (in frog embryos, as well as mice).
This resulted in his seminal paper: Cationic liposome-mediated RNA transfection RW Malone, PL Felgner, IM Verma. Proceedings of the National Academy of Sciences (PNAS) 86 (16), 6077-6081His filed patent and disclosures from the Salk included in-vivo RNA transfection and also methods for mRNA stabilization - now being claimed as invented by others. These are available for review.
His research was continued at Vical in 1989, where the first in-vivo mammalian rat experiments were designed by him. The mRNA, constructs, reagents were developed at the Salk institute and at Vical by Dr. Malone, this included dosing amounts for the in-vivo experiments. RNA and DNA were sent to Dr. Jon Wolff via Fedex. Dr.Wolff at the University of Wisconsin injected mice and rats. The initial patent disclosures for RNA and DNA vaccination were written by Dr. Malone in 1988-1989. Dr. Malone was also an inventor of DNA vaccines in 1988 and 1989.
This body of work resulted in over 10 patents and numerous publications, yielding about 7000 citations for this work. The paper was the first showing data for DNA and RNA side by side for in-vivo (the first paper for in-vivo DNA):Direct gene transfer into mouse muscle in vivo. Wolff JA, Malone RW, et al. Science. 1990;247(4949 Pt 1):1465-8. Cited in 4,750 articles, is the result of that work.
In 1989, research was performed that gave rise to the 10+ groundbreaking patents on mRNA vaccination, all with a priority date of March 3, 1989. This is the same priority date as the Salk Patent application, showing that the two institutions were working together (without Robert’s knowledge). These patents are the first published research on mRNA vaccination. The titles and links to the patents are listed in the documents below. These patents have proof of principle experiments on mRNA vaccines - that clearly document that the invention worked and that these are the first experiments showing this.
Vical was to license the Salk Technology. Instead, they hired Robert’s thesis advisor from the Salk and soon after, the Salk dropped the patent and Vical never pursued a license from the Salk. Due to an employee contract with Vical, this stopped Robert from working in the field commercially for a decade. Vical claimed all the Salk research happened at Vical and sent a cease and desist letter.
Dr. Malone carried on his research into mRNA vaccination during the 1990s, culminating in a mucosal patent that was issued in 2000. He also helped revolutionized the field of cationic liposomes for the use in RNA vaccinations. This work was so far ahead of its time, that only now is the world turning to mucosal mRNA vaccination as a method of immunization. For a listing of some of his work, see the publications at the end of this page.
Scientifically trained at UC Davis, UC San Diego, and at the Salk Institute Molecular Biology and Virology laboratories, Dr. Malone received his medical training at Northwestern University (MD) and Harvard University Medical School (Clinical Research Post Graduate) , and in Pathology at UC Davis, He has almost 100 peer-reviewed publications, and has been an invited speaker at about 50 conferences.0 -
All of them were. Could you imagine the media coverage had they all had an "R" after their names?nicknyr15 said:Were those Texas democrats who caught the virus all vaccinated?It’s sad that I have to even type this but I’m legitimately asking, not instigating or trying to prove any point.
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@gvn2fly1421 wait until you see all the cool things I have done, as evidenced on what I put on my LLC page when trying to drive my consulting business.0
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6 have tested positive out of 60 that went. That's a 10% infection rate, for all of you non math majors. And what is the estimated efficacy rate of the vaccines against the delta variant? According to research, somewhere in the 80's https://www.healthline.com/health-news/heres-how-well-covid-19-vaccines-work-against-the-delta-variant#Vaccines-vs.-delta-variantgvn2fly1421 said:
All of them were. Could you imagine the media coverage had they all had an "R" after their names?nicknyr15 said:Were those Texas democrats who caught the virus all vaccinated?It’s sad that I have to even type this but I’m legitimately asking, not instigating or trying to prove any point.
Now 60 people is not statistically significant, so there could have been 3 infections, or 20 and the studies could still be right. But to anticipate zero cases when there was someone in there obviously infected, would be an unwise expectation.0 -
I hear ya. And I updated my original post stating that him being the inventor was a disputed claim.mrussel1 said:@gvn2fly1421 wait until you see all the cool things I have done, as evidenced on what I put on my LLC page when trying to drive my consulting business.
But again, so weird to continue to consider yourself that when it is so easy to disprove, right?0 -
Thank you @mrussel1 for researching and posting the factual info.
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I'm constantly stunned by how many liars are out there...good reason to be careful. Thank you for updating your post.
Falling down,...not staying down0 -
i don't know, but they all look pretty stupid now in those photos taken on the plane with none of them wearing masks.nicknyr15 said:Were those Texas democrats who caught the virus all vaccinated?It’s sad that I have to even type this but I’m legitimately asking, not instigating or trying to prove any point."You can tell the greatness of a man by what makes him angry." - Lincoln
"Well, you tell him that I don't talk to suckas."0 -
i mean ffs, you are all on a plane in close quarters, wear a mask to protect yourself and everyone else.gimmesometruth27 said:
i don't know, but they all look pretty stupid now in those photos taken on the plane with none of them wearing masks.nicknyr15 said:Were those Texas democrats who caught the virus all vaccinated?It’s sad that I have to even type this but I’m legitimately asking, not instigating or trying to prove any point."You can tell the greatness of a man by what makes him angry." - Lincoln
"Well, you tell him that I don't talk to suckas."0 -
I was swimming in the Great Barrier Reef
Animals were hiding behind the Coral
Except for little Turtle
I could swear he's trying to talk to me
Gurgle Gurgle0 -
But I thought the mRNA vaccine was rushed, being all new and all?gvn2fly1421 said:Weird then that he is still parading himself on twitter that way and his website still claims that. Regardless, I think his points are pretty spot on.
https://www.rwmalonemd.com/mrna-vaccine-inventorIT ALL STARTED WHEN…
Dr. Malone is the inventor of mRNA vaccines (and DNA vaccines). He also discovered lipid mediated and naked RNA transfection technologies.
It all started when he was at the Salk Institute in 1987 and 1988. There, he pioneered in-vitro RNA transfection and also in-vivo RNA transfection (in frog embryos, as well as mice).
This resulted in his seminal paper: Cationic liposome-mediated RNA transfection RW Malone, PL Felgner, IM Verma. Proceedings of the National Academy of Sciences (PNAS) 86 (16), 6077-6081His filed patent and disclosures from the Salk included in-vivo RNA transfection and also methods for mRNA stabilization - now being claimed as invented by others. These are available for review.
His research was continued at Vical in 1989, where the first in-vivo mammalian rat experiments were designed by him. The mRNA, constructs, reagents were developed at the Salk institute and at Vical by Dr. Malone, this included dosing amounts for the in-vivo experiments. RNA and DNA were sent to Dr. Jon Wolff via Fedex. Dr.Wolff at the University of Wisconsin injected mice and rats. The initial patent disclosures for RNA and DNA vaccination were written by Dr. Malone in 1988-1989. Dr. Malone was also an inventor of DNA vaccines in 1988 and 1989.
This body of work resulted in over 10 patents and numerous publications, yielding about 7000 citations for this work. The paper was the first showing data for DNA and RNA side by side for in-vivo (the first paper for in-vivo DNA):Direct gene transfer into mouse muscle in vivo. Wolff JA, Malone RW, et al. Science. 1990;247(4949 Pt 1):1465-8. Cited in 4,750 articles, is the result of that work.
In 1989, research was performed that gave rise to the 10+ groundbreaking patents on mRNA vaccination, all with a priority date of March 3, 1989. This is the same priority date as the Salk Patent application, showing that the two institutions were working together (without Robert’s knowledge). These patents are the first published research on mRNA vaccination. The titles and links to the patents are listed in the documents below. These patents have proof of principle experiments on mRNA vaccines - that clearly document that the invention worked and that these are the first experiments showing this.
Vical was to license the Salk Technology. Instead, they hired Robert’s thesis advisor from the Salk and soon after, the Salk dropped the patent and Vical never pursued a license from the Salk. Due to an employee contract with Vical, this stopped Robert from working in the field commercially for a decade. Vical claimed all the Salk research happened at Vical and sent a cease and desist letter.
Dr. Malone carried on his research into mRNA vaccination during the 1990s, culminating in a mucosal patent that was issued in 2000. He also helped revolutionized the field of cationic liposomes for the use in RNA vaccinations. This work was so far ahead of its time, that only now is the world turning to mucosal mRNA vaccination as a method of immunization. For a listing of some of his work, see the publications at the end of this page.
Scientifically trained at UC Davis, UC San Diego, and at the Salk Institute Molecular Biology and Virology laboratories, Dr. Malone received his medical training at Northwestern University (MD) and Harvard University Medical School (Clinical Research Post Graduate) , and in Pathology at UC Davis, He has almost 100 peer-reviewed publications, and has been an invited speaker at about 50 conferences.09/15/1998 & 09/16/1998, Mansfield, MA; 08/29/00 08/30/00, Mansfield, MA; 07/02/03, 07/03/03, Mansfield, MA; 09/28/04, 09/29/04, Boston, MA; 09/22/05, Halifax, NS; 05/24/06, 05/25/06, Boston, MA; 07/22/06, 07/23/06, Gorge, WA; 06/27/2008, Hartford; 06/28/08, 06/30/08, Mansfield; 08/18/2009, O2, London, UK; 10/30/09, 10/31/09, Philadelphia, PA; 05/15/10, Hartford, CT; 05/17/10, Boston, MA; 05/20/10, 05/21/10, NY, NY; 06/22/10, Dublin, IRE; 06/23/10, Northern Ireland; 09/03/11, 09/04/11, Alpine Valley, WI; 09/11/11, 09/12/11, Toronto, Ont; 09/14/11, Ottawa, Ont; 09/15/11, Hamilton, Ont; 07/02/2012, Prague, Czech Republic; 07/04/2012 & 07/05/2012, Berlin, Germany; 07/07/2012, Stockholm, Sweden; 09/30/2012, Missoula, MT; 07/16/2013, London, Ont; 07/19/2013, Chicago, IL; 10/15/2013 & 10/16/2013, Worcester, MA; 10/21/2013 & 10/22/2013, Philadelphia, PA; 10/25/2013, Hartford, CT; 11/29/2013, Portland, OR; 11/30/2013, Spokane, WA; 12/04/2013, Vancouver, BC; 12/06/2013, Seattle, WA; 10/03/2014, St. Louis. MO; 10/22/2014, Denver, CO; 10/26/2015, New York, NY; 04/23/2016, New Orleans, LA; 04/28/2016 & 04/29/2016, Philadelphia, PA; 05/01/2016 & 05/02/2016, New York, NY; 05/08/2016, Ottawa, Ont.; 05/10/2016 & 05/12/2016, Toronto, Ont.; 08/05/2016 & 08/07/2016, Boston, MA; 08/20/2016 & 08/22/2016, Chicago, IL; 07/01/2018, Prague, Czech Republic; 07/03/2018, Krakow, Poland; 07/05/2018, Berlin, Germany; 09/02/2018 & 09/04/2018, Boston, MA; 09/08/2022, Toronto, Ont; 09/11/2022, New York, NY; 09/14/2022, Camden, NJ; 09/02/2023, St. Paul, MN; 05/04/2024 & 05/06/2024, Vancouver, BC; 05/10/2024, Portland, OR;
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This was the first vaccine using the technology I believe. Definitely wouldn't call it rushed, rather groundbreaking.Halifax2TheMax said:
But I thought the mRNA vaccine was rushed, being all new and all?gvn2fly1421 said:Weird then that he is still parading himself on twitter that way and his website still claims that. Regardless, I think his points are pretty spot on.
https://www.rwmalonemd.com/mrna-vaccine-inventorIT ALL STARTED WHEN…
Dr. Malone is the inventor of mRNA vaccines (and DNA vaccines). He also discovered lipid mediated and naked RNA transfection technologies.
It all started when he was at the Salk Institute in 1987 and 1988. There, he pioneered in-vitro RNA transfection and also in-vivo RNA transfection (in frog embryos, as well as mice).
This resulted in his seminal paper: Cationic liposome-mediated RNA transfection RW Malone, PL Felgner, IM Verma. Proceedings of the National Academy of Sciences (PNAS) 86 (16), 6077-6081His filed patent and disclosures from the Salk included in-vivo RNA transfection and also methods for mRNA stabilization - now being claimed as invented by others. These are available for review.
His research was continued at Vical in 1989, where the first in-vivo mammalian rat experiments were designed by him. The mRNA, constructs, reagents were developed at the Salk institute and at Vical by Dr. Malone, this included dosing amounts for the in-vivo experiments. RNA and DNA were sent to Dr. Jon Wolff via Fedex. Dr.Wolff at the University of Wisconsin injected mice and rats. The initial patent disclosures for RNA and DNA vaccination were written by Dr. Malone in 1988-1989. Dr. Malone was also an inventor of DNA vaccines in 1988 and 1989.
This body of work resulted in over 10 patents and numerous publications, yielding about 7000 citations for this work. The paper was the first showing data for DNA and RNA side by side for in-vivo (the first paper for in-vivo DNA):Direct gene transfer into mouse muscle in vivo. Wolff JA, Malone RW, et al. Science. 1990;247(4949 Pt 1):1465-8. Cited in 4,750 articles, is the result of that work.
In 1989, research was performed that gave rise to the 10+ groundbreaking patents on mRNA vaccination, all with a priority date of March 3, 1989. This is the same priority date as the Salk Patent application, showing that the two institutions were working together (without Robert’s knowledge). These patents are the first published research on mRNA vaccination. The titles and links to the patents are listed in the documents below. These patents have proof of principle experiments on mRNA vaccines - that clearly document that the invention worked and that these are the first experiments showing this.
Vical was to license the Salk Technology. Instead, they hired Robert’s thesis advisor from the Salk and soon after, the Salk dropped the patent and Vical never pursued a license from the Salk. Due to an employee contract with Vical, this stopped Robert from working in the field commercially for a decade. Vical claimed all the Salk research happened at Vical and sent a cease and desist letter.
Dr. Malone carried on his research into mRNA vaccination during the 1990s, culminating in a mucosal patent that was issued in 2000. He also helped revolutionized the field of cationic liposomes for the use in RNA vaccinations. This work was so far ahead of its time, that only now is the world turning to mucosal mRNA vaccination as a method of immunization. For a listing of some of his work, see the publications at the end of this page.
Scientifically trained at UC Davis, UC San Diego, and at the Salk Institute Molecular Biology and Virology laboratories, Dr. Malone received his medical training at Northwestern University (MD) and Harvard University Medical School (Clinical Research Post Graduate) , and in Pathology at UC Davis, He has almost 100 peer-reviewed publications, and has been an invited speaker at about 50 conferences.0 -
Was it a chartered jet? If so, then I don't think it's stupid if everyone had the vaccine. Igimmesometruth27 said:
i mean ffs, you are all on a plane in close quarters, wear a mask to protect yourself and everyone else.gimmesometruth27 said:
i don't know, but they all look pretty stupid now in those photos taken on the plane with none of them wearing masks.nicknyr15 said:Were those Texas democrats who caught the virus all vaccinated?It’s sad that I have to even type this but I’m legitimately asking, not instigating or trying to prove any point.0 -
I was being facetious as that was one of the claims thrown about by a certain poster regarding vaccine hesitancy. That it was “rushed.”mrussel1 said:
This was the first vaccine using the technology I believe. Definitely wouldn't call it rushed, rather groundbreaking.Halifax2TheMax said:
But I thought the mRNA vaccine was rushed, being all new and all?gvn2fly1421 said:Weird then that he is still parading himself on twitter that way and his website still claims that. Regardless, I think his points are pretty spot on.
https://www.rwmalonemd.com/mrna-vaccine-inventorIT ALL STARTED WHEN…
Dr. Malone is the inventor of mRNA vaccines (and DNA vaccines). He also discovered lipid mediated and naked RNA transfection technologies.
It all started when he was at the Salk Institute in 1987 and 1988. There, he pioneered in-vitro RNA transfection and also in-vivo RNA transfection (in frog embryos, as well as mice).
This resulted in his seminal paper: Cationic liposome-mediated RNA transfection RW Malone, PL Felgner, IM Verma. Proceedings of the National Academy of Sciences (PNAS) 86 (16), 6077-6081His filed patent and disclosures from the Salk included in-vivo RNA transfection and also methods for mRNA stabilization - now being claimed as invented by others. These are available for review.
His research was continued at Vical in 1989, where the first in-vivo mammalian rat experiments were designed by him. The mRNA, constructs, reagents were developed at the Salk institute and at Vical by Dr. Malone, this included dosing amounts for the in-vivo experiments. RNA and DNA were sent to Dr. Jon Wolff via Fedex. Dr.Wolff at the University of Wisconsin injected mice and rats. The initial patent disclosures for RNA and DNA vaccination were written by Dr. Malone in 1988-1989. Dr. Malone was also an inventor of DNA vaccines in 1988 and 1989.
This body of work resulted in over 10 patents and numerous publications, yielding about 7000 citations for this work. The paper was the first showing data for DNA and RNA side by side for in-vivo (the first paper for in-vivo DNA):Direct gene transfer into mouse muscle in vivo. Wolff JA, Malone RW, et al. Science. 1990;247(4949 Pt 1):1465-8. Cited in 4,750 articles, is the result of that work.
In 1989, research was performed that gave rise to the 10+ groundbreaking patents on mRNA vaccination, all with a priority date of March 3, 1989. This is the same priority date as the Salk Patent application, showing that the two institutions were working together (without Robert’s knowledge). These patents are the first published research on mRNA vaccination. The titles and links to the patents are listed in the documents below. These patents have proof of principle experiments on mRNA vaccines - that clearly document that the invention worked and that these are the first experiments showing this.
Vical was to license the Salk Technology. Instead, they hired Robert’s thesis advisor from the Salk and soon after, the Salk dropped the patent and Vical never pursued a license from the Salk. Due to an employee contract with Vical, this stopped Robert from working in the field commercially for a decade. Vical claimed all the Salk research happened at Vical and sent a cease and desist letter.
Dr. Malone carried on his research into mRNA vaccination during the 1990s, culminating in a mucosal patent that was issued in 2000. He also helped revolutionized the field of cationic liposomes for the use in RNA vaccinations. This work was so far ahead of its time, that only now is the world turning to mucosal mRNA vaccination as a method of immunization. For a listing of some of his work, see the publications at the end of this page.
Scientifically trained at UC Davis, UC San Diego, and at the Salk Institute Molecular Biology and Virology laboratories, Dr. Malone received his medical training at Northwestern University (MD) and Harvard University Medical School (Clinical Research Post Graduate) , and in Pathology at UC Davis, He has almost 100 peer-reviewed publications, and has been an invited speaker at about 50 conferences.09/15/1998 & 09/16/1998, Mansfield, MA; 08/29/00 08/30/00, Mansfield, MA; 07/02/03, 07/03/03, Mansfield, MA; 09/28/04, 09/29/04, Boston, MA; 09/22/05, Halifax, NS; 05/24/06, 05/25/06, Boston, MA; 07/22/06, 07/23/06, Gorge, WA; 06/27/2008, Hartford; 06/28/08, 06/30/08, Mansfield; 08/18/2009, O2, London, UK; 10/30/09, 10/31/09, Philadelphia, PA; 05/15/10, Hartford, CT; 05/17/10, Boston, MA; 05/20/10, 05/21/10, NY, NY; 06/22/10, Dublin, IRE; 06/23/10, Northern Ireland; 09/03/11, 09/04/11, Alpine Valley, WI; 09/11/11, 09/12/11, Toronto, Ont; 09/14/11, Ottawa, Ont; 09/15/11, Hamilton, Ont; 07/02/2012, Prague, Czech Republic; 07/04/2012 & 07/05/2012, Berlin, Germany; 07/07/2012, Stockholm, Sweden; 09/30/2012, Missoula, MT; 07/16/2013, London, Ont; 07/19/2013, Chicago, IL; 10/15/2013 & 10/16/2013, Worcester, MA; 10/21/2013 & 10/22/2013, Philadelphia, PA; 10/25/2013, Hartford, CT; 11/29/2013, Portland, OR; 11/30/2013, Spokane, WA; 12/04/2013, Vancouver, BC; 12/06/2013, Seattle, WA; 10/03/2014, St. Louis. MO; 10/22/2014, Denver, CO; 10/26/2015, New York, NY; 04/23/2016, New Orleans, LA; 04/28/2016 & 04/29/2016, Philadelphia, PA; 05/01/2016 & 05/02/2016, New York, NY; 05/08/2016, Ottawa, Ont.; 05/10/2016 & 05/12/2016, Toronto, Ont.; 08/05/2016 & 08/07/2016, Boston, MA; 08/20/2016 & 08/22/2016, Chicago, IL; 07/01/2018, Prague, Czech Republic; 07/03/2018, Krakow, Poland; 07/05/2018, Berlin, Germany; 09/02/2018 & 09/04/2018, Boston, MA; 09/08/2022, Toronto, Ont; 09/11/2022, New York, NY; 09/14/2022, Camden, NJ; 09/02/2023, St. Paul, MN; 05/04/2024 & 05/06/2024, Vancouver, BC; 05/10/2024, Portland, OR;
Libtardaplorable©. And proud of it.
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He probably does it knowing the vast majority of people won't fact check what he claims for qualifications.gvn2fly1421 said:mrussel1 said:@gvn2fly1421 wait until you see all the cool things I have done, as evidenced on what I put on my LLC page when trying to drive my consulting business.
But again, so weird to continue to consider yourself that when it is so easy to disprove, right?
And certainly those who align with what he puts out on Twitter won't try to find reason to discredit his resume.This weekend we rock Portland0 -
yes. but still. set an example. i mean they already ran away from their job, set an example.mrussel1 said:
Was it a chartered jet? If so, then I don't think it's stupid if everyone had the vaccine. Igimmesometruth27 said:
i mean ffs, you are all on a plane in close quarters, wear a mask to protect yourself and everyone else.gimmesometruth27 said:
i don't know, but they all look pretty stupid now in those photos taken on the plane with none of them wearing masks.nicknyr15 said:Were those Texas democrats who caught the virus all vaccinated?It’s sad that I have to even type this but I’m legitimately asking, not instigating or trying to prove any point."You can tell the greatness of a man by what makes him angry." - Lincoln
"Well, you tell him that I don't talk to suckas."0 -
I think they were following cdc guidelines. I personally don't have an issue with it.gimmesometruth27 said:
yes. but still. set an example. i mean they already ran away from their job, set an example.mrussel1 said:
Was it a chartered jet? If so, then I don't think it's stupid if everyone had the vaccine. Igimmesometruth27 said:
i mean ffs, you are all on a plane in close quarters, wear a mask to protect yourself and everyone else.gimmesometruth27 said:
i don't know, but they all look pretty stupid now in those photos taken on the plane with none of them wearing masks.nicknyr15 said:Were those Texas democrats who caught the virus all vaccinated?It’s sad that I have to even type this but I’m legitimately asking, not instigating or trying to prove any point.0 -
I thought I'd read that they made a vaccine for SARS, and that vaccine is kind of gave them a legs up on using the same tech for a Covid19 vaccine?mrussel1 said:
This was the first vaccine using the technology I believe. Definitely wouldn't call it rushed, rather groundbreaking.Halifax2TheMax said:
But I thought the mRNA vaccine was rushed, being all new and all?gvn2fly1421 said:Weird then that he is still parading himself on twitter that way and his website still claims that. Regardless, I think his points are pretty spot on.
https://www.rwmalonemd.com/mrna-vaccine-inventorIT ALL STARTED WHEN…
Dr. Malone is the inventor of mRNA vaccines (and DNA vaccines). He also discovered lipid mediated and naked RNA transfection technologies.
It all started when he was at the Salk Institute in 1987 and 1988. There, he pioneered in-vitro RNA transfection and also in-vivo RNA transfection (in frog embryos, as well as mice).
This resulted in his seminal paper: Cationic liposome-mediated RNA transfection RW Malone, PL Felgner, IM Verma. Proceedings of the National Academy of Sciences (PNAS) 86 (16), 6077-6081His filed patent and disclosures from the Salk included in-vivo RNA transfection and also methods for mRNA stabilization - now being claimed as invented by others. These are available for review.
His research was continued at Vical in 1989, where the first in-vivo mammalian rat experiments were designed by him. The mRNA, constructs, reagents were developed at the Salk institute and at Vical by Dr. Malone, this included dosing amounts for the in-vivo experiments. RNA and DNA were sent to Dr. Jon Wolff via Fedex. Dr.Wolff at the University of Wisconsin injected mice and rats. The initial patent disclosures for RNA and DNA vaccination were written by Dr. Malone in 1988-1989. Dr. Malone was also an inventor of DNA vaccines in 1988 and 1989.
This body of work resulted in over 10 patents and numerous publications, yielding about 7000 citations for this work. The paper was the first showing data for DNA and RNA side by side for in-vivo (the first paper for in-vivo DNA):Direct gene transfer into mouse muscle in vivo. Wolff JA, Malone RW, et al. Science. 1990;247(4949 Pt 1):1465-8. Cited in 4,750 articles, is the result of that work.
In 1989, research was performed that gave rise to the 10+ groundbreaking patents on mRNA vaccination, all with a priority date of March 3, 1989. This is the same priority date as the Salk Patent application, showing that the two institutions were working together (without Robert’s knowledge). These patents are the first published research on mRNA vaccination. The titles and links to the patents are listed in the documents below. These patents have proof of principle experiments on mRNA vaccines - that clearly document that the invention worked and that these are the first experiments showing this.
Vical was to license the Salk Technology. Instead, they hired Robert’s thesis advisor from the Salk and soon after, the Salk dropped the patent and Vical never pursued a license from the Salk. Due to an employee contract with Vical, this stopped Robert from working in the field commercially for a decade. Vical claimed all the Salk research happened at Vical and sent a cease and desist letter.
Dr. Malone carried on his research into mRNA vaccination during the 1990s, culminating in a mucosal patent that was issued in 2000. He also helped revolutionized the field of cationic liposomes for the use in RNA vaccinations. This work was so far ahead of its time, that only now is the world turning to mucosal mRNA vaccination as a method of immunization. For a listing of some of his work, see the publications at the end of this page.
Scientifically trained at UC Davis, UC San Diego, and at the Salk Institute Molecular Biology and Virology laboratories, Dr. Malone received his medical training at Northwestern University (MD) and Harvard University Medical School (Clinical Research Post Graduate) , and in Pathology at UC Davis, He has almost 100 peer-reviewed publications, and has been an invited speaker at about 50 conferences.0
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