Cancer Treatments
Flutter Girl
Posts: 548
Anyone hear of the one where they use gold cos it goes right into the sick cells so they can target only the cancerous ones, instead of killing even the healthy ones like chemo? I'm desperate to find the best most effective way to help my mum so any other treatments I haven't heard of would be unbelievably appreciated! 
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I'm also unfortunately sure the one I mentioned is not even ready for trials on people yet.
but i've never heard of the treatment you're suggesting.
i know i'm not the op but this still very important to me.
Most of them work by inhibiting an enzyme called thioredoxin reductase which is over-expressed in cancer cells. Others work on "re-activating" apoptosis (cell death) in cancer cells. I'll have to compile a list of compounds that are currently being tested, mainly in animal models though. I've read about a few trials going on in the US.
- PX-12 (1-methylpropyl 2-imidazolyl disulfide, #141400-58-0, also called IV-2) has been tested in cancer patients.
Quoted from the review:
A number of compounds inhibit TrxR including organogold compounds, phosphole complexes, arsenicals, nitrosoureas, platinum complexes, quinoid compounds, para-quinones, polyphenols, nitroaromatic compounds, naphthoquinone spiroketal derivatives, organochalcogenides, motexafin gadolinium and flavonoids such as myricetin and quercetin. An important limitation of these compounds is that they can inhibit also other oxidoreductases; compounds with greater selectivity for TrxR than for other oxidoreductases include gold(I,III) complexes, organotellurium compounds and palmarumycin-based inhibitors.
Some of the names of these compounds: Auranofin, cisplatin, transplatin, oxaliplatin, arsenic trioxide, sulforaphane, Ebselen, BBSKE, organotellurium steroid, curcumin, carmustine, iomustine, nimustine, fotemustine, chlorambucil, melphalan and cyclophosphamide. There are many more.
how realistic is it that we'll see this treatment in the near future, and how effective do you think it is?
I found some info on the one I was talking about and it does appear to still not yet have any trials for people..It's the nano particles (or somert) of gold. It gets into the cells cause of how sick cells have holes, and they use some kind of critter of a machine that goes right over where the cancer is and kills the cells with the gold in it. It's an alternative to chemo, and from my understanding they are having near 100%, if not fully 100%, success with it..
The main aim of the research is to develop compounds that are more effective and more specific towards cancer cells. The drugs used at the moment as everyone knows have negative effects on normal cells of the body. This will be extremely hard to abolish completely but the new compounds developed will likely replace the current ones in use. They will also be combined with radiation therapy as is done already in some cases.
Edit: Very realistic and much more effective than now because our understanding of cancer has developed over the years.
What type of cancer does your mother have? The treatment may differ as they have found compounds that specifically target gastric cancer cells for example. As for the nanoparticles, sorry I can't give you much help there. Some are still under Phase I trials and others are still waiting approval for trials. The chemotherapeutic drugs I mentioned some have already undergone trials and were shown to be effective.
Ill try to explain the mechanism behind the drugs.
Cancer cells produce a larger quantity of an enzyme called thioredoxin reductase. This makes them extremely resistant to oxidative stress and eventually stops apoptosis from occuring. This discovery has led scientists to develop a drug that inhibits this enzyme which would make the levels go back to normal. That would eventually lead the cancer cells to re-activate apoptosis and die. The compounds I posted above have this specific mechanism of action (inhibition of thioredoxin reductase).
Hope that helps. We can discuss this in private if you think if might help.
They haven't said it is cancer yet. They won't have the results till monday. But the cancer expert at the hospital was very insistent that they are almost certain it is because the CT scan showed spots along her breast bone and brain, and one in her lung. There was also a lot of fluid around her heart which is something attributed to cancer.
Theres a review on Nanoparticle delivery systems here:
http://www.ncbi.nlm.nih.gov/pubmed/1909 ... d_RVDocSum
I might have subscription to this journal at my work so if your interested tell me.
Also, if you are interested in how to participate in clinical trials you should have a look at this website:
http://www.cancer.gov/clinicaltrials
I'm sorry to hear that. I work in clinical cancer research and can tell you that there are some pretty incredible drugs that are in early phase trials...specific to certain cancer types.
Feel free to PM me if you have any questions about anything.
I am using nano silver to boost my immune system. I had an upper respitory infection the day before Christmas and finally went to the doctor after about a week. The antibiotics didn't kick it...A friend recommended Nutronix to me and I have been taking it about 3 weeks now. My infection is finally starting to break up.
Here is a video about the Gold in which you have heard about, a physics friend introduced me to.
1.5 hour in length: very fruitful
http://video.google.com/videoplay?docid ... 0048711403
peace and love your way...
_________________
a derivitive of nature.
nature is god
god is love
love is light
Thank you for that...I have a little more specific info today. They found 3 nodules in her lung, one on her breast bone, and 3 in the brain, and all are very tiny, they said..
Yes definately, I am very interested in the article if you do indeed have a subscription..And the info is invaluable, I'm particularly going to be looking into the Indian company..
Thanks for that information melodious, I had wanted to get a much better understanding of it than I had already found online..so that is much appreciated.
I'm sending a pm your way mca..The more I can learn about it, the better. I know with my grandad, he had a horrible death. He was a very heavy smoker and got cancer in the voicebox, or somert, first and they had to remove the whole thing. Then it showed up in his lungs and spread out everywhere from there. My mum was only 16 when he died..
a derivitive of nature.
nature is god
god is love
love is light
I cannot stress it enough for all of you to regularly be checked for melanoma. You don't have to be in the sun much to get it. stage one is the easiest cancer to treat of all cancer's. stage four is the most difficult of all cancers with only a 10% survival rate.
I wish you all the best. In my language, instead of saying goodbye(cos you only do this if it is forever), we say sastipen. It means good health. I think it is fitting here, so sastipen everyone
-Rebekka
EDIT: she passed about 6.30 this morning. The cancer spread so aggressively the past 3 days, with a new tumor showing up, along with bleeding, in the brain, and fluid and the cancer both penetrating the heart. The doctor's have all said what shock they are in because they have never seen anything like this happen. Leave it to my mama to be different.
It was comforting to see all the nurses and doctors coming in with disbelief, fighting crying, cos she is a patient that truely touched their hearts within the short month she was there. she was everyone's favourite up there, they all kept telling me that the entire time she was in the hospital. she was a very special lady in that way, and not just in the hospital..everywhere she went.
When I said she was gone before, I meant she was considered brain dead. In case there is any confusion.