Any vintage strat pickups through a tube amp will get you close. I play a John Mayer strat through a blues jr, and can get very nice yellow ledbetter like tones out of it. Those pick-ups are based off Texas Specials which are found in a SRV strat. They sound great with overdrive too.
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check out 54's
http://accessories.musiciansfriend.com/product/Fender-Custom-Shop-54-Strat-Pickups-Set-of-3?sku=301624
or anything from lindy fralin (blues specials are supposed to be great)
http://www.fralinpickups.com/stratstyle.asp
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Fender's Texas Specials would work pretty well, too.
Fralin Vintage Hot's are a good pick too. I LOVE lindy fralin.
there are some sound clips over at Acme guitar works page if you want to compare.
As far as I know the pickups in his 59 are stock... but keep in mind age and everything.
your hands, a nice big speaker cabinet and single coil alnico magnets should pretty much get you there anyway.