Cannabinoids - National Cancer Institute Strongly Affirms Anti-Tumor Properties

DriftingByTheStorm · July 2014

What THE Fuck, ya'll !?!
I've had a few friends come up to me lately and mention the following,
however, having been drawn down some rabbit holes before, I was quite skeptical but ...
came across a facebook post this morning with supposed evidence,
then went searching for my own "proof"

came up with:
US GOVERNMENT - NATIONAL INSTITUTE OF HEALTH \ NATIONAL CANCER INSTITUTE:
THIS IS ONLY THE JUCIEST PART OF A LONGER ARTICLE:

Cannabinoids may cause antitumor effects by various mechanisms, including induction of cell death, inhibition of cell growth, and inhibition of tumor angiogenesis invasion and metastasis.[9-12] Two reviews summarize the molecular mechanisms of action of cannabinoids as antitumor agents.[13,14] Cannabinoids appear to kill tumor cells but do not affect their nontransformed counterparts and may even protect them from cell death. These compounds have been shown to induce apoptosis in glioma cells in culture and induce regression of glioma tumors in mice and rats. Cannabinoids protect normal glial cells of astroglial and oligodendroglial lineages from apoptosis mediated by the CB1 receptor.[15]

WHAT

THE

FUCK

!!??!??!!

hedonist · July 2014

I'm glad the beneficial effects of this weed are being seriously considered.

A fellow smoker/co-worker told me about this finding a few months ago, but I hadn't seen anything about it until recently.

In fact, I should've mentioned it to my mom - just got back from a b-day lunch with her, and told her I got my MM card last year. She said "honey, please don't overdo it".

Sure, Mom. Now please read this article

elvistheking44 · July 2014

Read the first three words of your excerpt from the article.

amethgr8 · July 2014

Can minus may cause anti-tumor

amethgr8 · July 2014

This. For years prob. And flax too.

Godfather. · July 2014

some say that there is a cure for cancer.......but then again cancer is a $1.6 billion a year business, what would happen to all the cancer research centers that collect millions of dollars a year from the public and in grants and not to mention the thousands of jobs that have been created to feed this machine,reminds me of the man made global warming issue/debate/hoax what ever you want to call it both these subjects generate $billions every year for groups-research centers-politicans etc. come to think of it this could be exactly why pot/drugs will never be legalized, just think of the funding and jobs related to it...the monies distributed thru-out the country and billions sized in anual bust's must be staggering and at the end of the day we are left debating the issues of these subjects and not maybe knowing the true motive for their existance......BIG MONEY ! anywhere in the world you go your being is simply related to money......sickening isn't it ? and your good health is a $ sign to the system.

Godfather.

rgambs · July 2014

NOTHING cures cancer! That is not really possible. A cure eliminates a malady by eliminating the pathogen creating sickness. Cancers (i hope you all know there are many types and many causes) are caused by mutations within ones genes that result in "bad" cells which usually do not function but do reproduce. To cure cancer would require fixing the genetic mutation which is still impossible for the near future. Cannabinoids definitely fight cancer, alongside many naturally occuring molecules. They may even excel at fighting cancers but cannabinoids will not cure cancer in general, nor will they cure cancer in an individual. There is some weighty evidence that a raw plant diet is capable of preventing much of the genetic mutation responsible for cancer so I would think the addition of cannabis use would further decrease your risk. We all need to live more like Native Americans. It would solve every problem mankind has created in the last few thousand years.

Shawshank · July 2014

When taking into consideration the many mutagenic elements in the food we eat (gmo's, caffeine, and most of the shit in processed food), there will never be a cure for cancer...ever. It's impossible to cure a disease that can be caused by the very genotoxins we ingest.

rgambs · July 2014

raw plant diet plus cannabis use equals good plan for not getting cancer... Fukushima aside.

DriftingByTheStorm · July 2014

elvistheking44 said:
Read the first three words of your excerpt from the article.

i see what you are trying to insinuate, but you can not abstract 3 words from their context.
The context is
"Cannabinoids may cause antitumor effects by various mechanisms"

The article is VERY clear that cannabinoids DO CAUSE antitumor effects.
All the sentence you are hinging on is claiming is that these KNOWN effects are caused by what MAY be VARIOUS different mechanisms. I think partially, it is an admission that the actions of the cannabinoids are not yet fully understood, and that the totality of mechanisms involved are possibly not all known.

It isn't saying that it MAY fight cancer.

So ...

Tenzing N. · July 2014

As someone who is currently fighting cancer I am so sick and tired of seeing these types of bullshit articles. Lemons cure cancer, weed cures cancer, vitamin D cures cancer. Until there are extensive clinical trials by multiple traditional sources, these articles only serve to create false hope and misdirected angst toward "big pharma".

hedonist · July 2014

As said in another thread, I wish you nothing but the best in your battle, Tenzing.

I'm with you on these types of studies - agree many are bullshit or money/agenda-driven, but I and many I know can attest to the benefits of weed. Perhaps not outright curing, but certainly alleviating, in so many ways.

Again, good wishes.

Tenzing N. · July 2014

Oh I fully agree with the alleviating benefits and I will never question that aspect after having used some to gain an appetite and eliminate pain. It was great. I just get so sick of these articles that claim anything is a cure and that something is being "hidden" or " suppressed" by the man.

Tenzing N. · July 2014

If tomorrow someone found out that xyz cured cancer my oncologist would give it to me. If he could get it for free he would give it to me for free.

callen · July 2014

Godfather. said:
some say that there is a cure for cancer.......but then again cancer is a $1.6 billion a year business, what would happen to all the cancer research centers that collect millions of dollars a year from the public and in grants and not to mention the thousands of jobs that have been created to feed this machine,reminds me of the man made global warming issue/debate/hoax what ever you want to call it both these subjects generate $billions every year for groups-research centers-politicans etc. come to think of it this could be exactly why pot/drugs will never be legalized, just think of the funding and jobs related to it...the monies distributed thru-out the country and billions sized in anual bust's must be staggering and at the end of the day we are left debating the issues of these subjects and not maybe knowing the true motive for their existance......BIG MONEY ! anywhere in the world you go your being is simply related to money......sickening isn't it ? and your good health is a $ sign to the system.

Godfather.

Let's not forget wars and guns for all.

Godfather. · July 2014

send lawyers guns and money to get me out alive. hahhahhhahhahah

Godfather.

DriftingByTheStorm · July 2014

Tenzing N. said:
Oh I fully agree with the alleviating benefits and I will never question that aspect after having used some to gain an appetite and eliminate pain. It was great. I just get so sick of these articles that claim anything is a cure and that something is being "hidden" or " suppressed" by the man.

DID YOU ACTUALLY READ THE FUCKING LINK?
IT IS "NATIONAL INSTITUTE OF HEALTH", AND IT IS EXTENSIVELY FOOTNOTED WITH SOURCE STUDIES.

??????????????????????????????????????????????????????????????

PS.
I DID NOT CLAIM ***SHIT*** ABOUT BEING SUPPRESSED.
I JUST PRESENTED YOU WITH A FACTUAL ARTICLE FROM A RELIABLE SOURCE.
?

Tenzing N. · July 2014

Yeah whatever.... I've read those articles. I've read that article. I've been pointed toward that article many times. YOUR FUCKING POST TITLE IS BULLSHIT! People who pass around this shit should go fuck themselves!

DriftingByTheStorm · July 2014

Here, let me help you since you have cancer, and are in disbelief:

One study in mice and rats suggested that cannabinoids may have a protective effect against the development of certain types of tumors.

and

Decreased incidences of benign tumors (polyps and adenomas) in other organs (mammary gland, uterus, pituitary, testis, and pancreas) were also noted in the rats.

Sourced from: National Toxicology Program: NTP toxicology and carcinogenesis studies of 1-trans-delta(9)-tetrahydrocannabinol (CAS No. 1972-08-3) in F344 rats and B6C3F1 mice (gavage studies). Natl Toxicol Program Tech Rep Ser 446 (): 1-317, 1996.

AND

In another study, delta-9-THC, delta-8-THC, and cannabinol were found to inhibit the growth of Lewis lung adenocarcinoma cells in vitro and in vivo

Sourced: Bifulco M, Laezza C, Pisanti S, et al.: Cannabinoids and cancer: pros and cons of an antitumour strategy. Br J Pharmacol 148 (2): 123-35, 2006.

AND

In addition, other tumors have been shown to be sensitive to cannabinoid-induced growth inhibition

FROM FOUR SOURCES:
Sánchez C, de Ceballos ML, Gomez del Pulgar T, et al.: Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor. Cancer Res 61 (15): 5784-9, 2001.

McKallip RJ, Lombard C, Fisher M, et al.: Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease. Blood 100 (2): 627-34, 2002.

Casanova ML, Blázquez C, Martínez-Palacio J, et al.: Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. J Clin Invest 111 (1): 43-50, 2003.

Blázquez C, González-Feria L, Alvarez L, et al.: Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas. Cancer Res 64 (16): 5617-23, 2004.

Cannabinoids may cause antitumor effects by various mechanisms, including induction of cell death, inhibition of cell growth, and inhibition of tumor angiogenesis invasion and metastasis.

SOURCE: Guzmán M: Cannabinoids: potential anticancer agents. Nat Rev Cancer 3 (10): 745-55, 2003.

Blázquez C, Casanova ML, Planas A, et al.: Inhibition of tumor angiogenesis by cannabinoids. FASEB J 17 (3): 529-31, 2003.

Vaccani A, Massi P, Colombo A, et al.: Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism. Br J Pharmacol 144 (8): 1032-6, 2005.

Ramer R, Bublitz K, Freimuth N, et al.: Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. FASEB J 26 (4): 1535-48, 2012.

AND

Two reviews summarize the molecular mechanisms of action of cannabinoids as antitumor agents.

SOURCE: Velasco G, Sánchez C, Guzmán M: Towards the use of cannabinoids as antitumour agents. Nat Rev Cancer 12 (6): 436-44, 2012.

Cridge BJ, Rosengren RJ: Critical appraisal of the potential use of cannabinoids in cancer management. Cancer Manag Res 5: 301-13, 2013.

Cannabinoids appear to kill tumor cells but do not affect their nontransformed counterparts and may even protect them from cell death. These compounds have been shown to induce apoptosis in glioma cells in culture and induce regression of glioma tumors in mice and rats. Cannabinoids protect normal glial cells of astroglial and oligodendroglial lineages from apoptosis mediated by the CB1 receptor.

Torres S, Lorente M, Rodríguez-Fornés F, et al.: A combined preclinical therapy of cannabinoids and temozolomide against glioma. Mol Cancer Ther 10 (1): 90-103, 2011.

THERE YOU GO.
THAT IS ONLY HALF OF THE ARTICLE.
IF YOU WANT MORE PROOF THAT IT IS SCHOLARLY AND NOT SOME HOAX BULLSHIT, I'M MORE THAN HAPPY TO CONTINUE FOR YOU.

I'M SORRY YOU HAVE CANCER.
YOU SHOULD TAKE THIS ARTICLE TO YOUR ONCOLOGIST.
AND SAY, "WHAT THE FUCK IS THIS SHIT HERE, DOC?!?"

DriftingByTheStorm · July 2014

elvistheking44 · July 2014

DriftingByTheStorm said:
Here, let me help you since you have cancer, and are in disbelief:

One study in mice and rats suggested that cannabinoids may have a protective effect against the development of certain types of tumors.

and

Decreased incidences of benign tumors (polyps and adenomas) in other organs (mammary gland, uterus, pituitary, testis, and pancreas) were also noted in the rats.

Sourced from: National Toxicology Program: NTP toxicology and carcinogenesis studies of 1-trans-delta(9)-tetrahydrocannabinol (CAS No. 1972-08-3) in F344 rats and B6C3F1 mice (gavage studies). Natl Toxicol Program Tech Rep Ser 446 (): 1-317, 1996.

AND

In another study, delta-9-THC, delta-8-THC, and cannabinol were found to inhibit the growth of Lewis lung adenocarcinoma cells in vitro and in vivo

Sourced: Bifulco M, Laezza C, Pisanti S, et al.: Cannabinoids and cancer: pros and cons of an antitumour strategy. Br J Pharmacol 148 (2): 123-35, 2006.

AND

In addition, other tumors have been shown to be sensitive to cannabinoid-induced growth inhibition

FROM FOUR SOURCES:
Sánchez C, de Ceballos ML, Gomez del Pulgar T, et al.: Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor. Cancer Res 61 (15): 5784-9, 2001.

McKallip RJ, Lombard C, Fisher M, et al.: Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease. Blood 100 (2): 627-34, 2002.

Casanova ML, Blázquez C, Martínez-Palacio J, et al.: Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. J Clin Invest 111 (1): 43-50, 2003.

Blázquez C, González-Feria L, Alvarez L, et al.: Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas. Cancer Res 64 (16): 5617-23, 2004.

Cannabinoids may cause antitumor effects by various mechanisms, including induction of cell death, inhibition of cell growth, and inhibition of tumor angiogenesis invasion and metastasis.

SOURCE: Guzmán M: Cannabinoids: potential anticancer agents. Nat Rev Cancer 3 (10): 745-55, 2003.

Blázquez C, Casanova ML, Planas A, et al.: Inhibition of tumor angiogenesis by cannabinoids. FASEB J 17 (3): 529-31, 2003.

Vaccani A, Massi P, Colombo A, et al.: Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism. Br J Pharmacol 144 (8): 1032-6, 2005.

Ramer R, Bublitz K, Freimuth N, et al.: Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. FASEB J 26 (4): 1535-48, 2012.

AND

Two reviews summarize the molecular mechanisms of action of cannabinoids as antitumor agents.

SOURCE: Velasco G, Sánchez C, Guzmán M: Towards the use of cannabinoids as antitumour agents. Nat Rev Cancer 12 (6): 436-44, 2012.

Cridge BJ, Rosengren RJ: Critical appraisal of the potential use of cannabinoids in cancer management. Cancer Manag Res 5: 301-13, 2013.

Cannabinoids appear to kill tumor cells but do not affect their nontransformed counterparts and may even protect them from cell death. These compounds have been shown to induce apoptosis in glioma cells in culture and induce regression of glioma tumors in mice and rats. Cannabinoids protect normal glial cells of astroglial and oligodendroglial lineages from apoptosis mediated by the CB1 receptor.

Torres S, Lorente M, Rodríguez-Fornés F, et al.: A combined preclinical therapy of cannabinoids and temozolomide against glioma. Mol Cancer Ther 10 (1): 90-103, 2011.

THERE YOU GO.
THAT IS ONLY HALF OF THE ARTICLE.
IF YOU WANT MORE PROOF THAT IT IS SCHOLARLY AND NOT SOME HOAX BULLSHIT, I'M MORE THAN HAPPY TO CONTINUE FOR YOU.

I'M SORRY YOU HAVE CANCER.
YOU SHOULD TAKE THIS ARTICLE TO YOUR ONCOLOGIST.
AND SAY, "WHAT THE FUCK IS THIS SHIT HERE, DOC?!?"

I'm sure his doctor would say "when an article continually repeats the words suggest to help, may help and appear to help" it can be swept under the rug. Are you purposely avoiding most of these things are quoted by yourself. I don't blame him for not getting on an uproar over this article.

DriftingByTheStorm · July 2014

You do not know how to read.

"Cannabinoids appear to kill tumor cells but do not affect their nontransformed counterparts and may even protect them from cell death. "

is written that way not becuase they "appear to" kill tumor cells, but because of the contradiction between what it does kill and does not kill.

It appears to kill TUMOR cells, but NOT nontransformed cells.
It is a factual observation, not a weak assumption couched behind wishy-washy language.

What else doesn't look strong enough about the bolded sentences above?

DriftingByTheStorm · July 2014

If articles citing scientific sources piss you off, how about this:

https://www.youtube.com/watch?v=I-Yzn27ps0I

Tenzing N. · July 2014

Steroids are making me edgy

DriftingByTheStorm · July 2014

Tenzing N. said:
Fuck you you god damned ignorant motherfucker! I hope you get cancer! Quit putting the word cure in anything! I'm sure I'll now get banned but I could fucking care less.

W

T

F

???

???

???

hedonist · July 2014

Tenzing, c'mon man. Totally unwarranted and unnecessarily hateful.

Shame a thread about something potentially amazingly beneficial went this route.

Tenzing N. · July 2014

Here's the deal. I have no doubt that studies were conducted... I have no doubt that the results may show some valid scientific data regarding the effects of cannaboids or whatever on tumors somehow but there's a huge problem. These are just primary, independent tests done on rats and mice and even those conducting the studies aren't entirely sure how the mechanisms work. But people with a love affair with pot and think that "the cancer networks" are trying to hide this keep passing along these articles like they are exposing some magic cure. And they keep putting the word cure in them like it really is that. Cancer sucks and the best treatments we currently have also suck. People are desperate for an alternative and representing things like this give people a false hope. So that's why I get so upset... Now why don't you edit your post title. You know its not a cure.

Kat · July 2014

Closed for review.

Cannabinoids - National Cancer Institute Strongly Affirms Anti-Tumor Properties

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