Seattle to San Francisco road trip - what to do?!

I'll be road tripping from Seattle to San Francisco in early September with some friends, just looking for some recommendations of things to do along the way. Obviously I have a few ideas sight-seeing wise, but I'd like some suggestions from locals - in particular for nights out in Seattle, Portland and San Francsico, but all other suggestions welcome too.
Cheers
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Trieste 14, Vienna 14, Gdynia 14, Leeds 14, Milton Keynes 14, Denver 14
Central Park 15
Fort Lauderdale 16, Miami 16, Tampa 16, Jacksonville 16, Greenville 16, Hampton 16, Columbia 16, Lexington 16, Philly1 16, Philly2 16, NYC1 16, NYC2 16, Quebec City 16, Ottawa 16, Toronto1 16, Toronto2 16, Fenway1 16, Fenway2 16, Wrigley1 16, Wrigley2 16
On US 101 at Leggett you have the option of taking CA 1 to coastal Mendocino County and on down into Sonoma and Marin Counties. The 36 miles from Leggitt to Rockport (where you'll hit the coast) is fairly nice BUT is a very winding road, so go easy. Once you hit the coast, you're in for some of the best CA coastal experiences. The Point Arena Lighthouse is marvelous. The little town of Mendocino is cool but crowded in the summer months. The coast is especially beautiful when you get to Sonoma county and that stretch is referred to as The Sonoma Coast. Salt Point State Park on the ocean side is a must see. Same with Point Reyes National Sea Shore, north of San Francisco. And then of course, you'll get to cross the magnificent Golden Gate Bridge.
IN SF, you probably be convinced to see Fisherman's Wharf which I guess is understandable and it's very "touristy" yet it's also not far from the great historic Beat Era bookstore, City Lights. But also maybe check out some other spots like the incredible view (if no fog) up on Twin Peaks, Fort Point at the base of the G.G. Bridge, Noe Valley, and Lands End. And of course Golden Gate Park is beautiful!
I wish I could recommend seeing the Sierras but in the late summer and fall with the fires we've been having it could be a bit of a let down. Very smokey!
In any case, have a great time!
House of Nanking (San Fran)
919 Kearny Street
Order the following:
Very casual place but awesome!
Right up the street from there is Jack Kerouac Alley by City Lights Bookstore
Cool little bar there (Vesuvio Cafe)
2012 Missoula (9/30) 2013 Chicago (7/19) Pittsburgh (10/11) Buffalo (10/12) Baltimore (10/27) Dallas (11/15)
2014 Austin (10/12) Memphis (10/14) St. Paul (10/19) Milwaukee (10/20) Denver (10/22)
2016 Ft. Lauderdale (4/8) Miami (4/9) Hampton (4/18) Philly (4/28,4/29) NY (5/1,5/2) 2018 Seattle (8/10) Missoula (8/13) 2022 Nashville (9/16)
E.V. - 2008 Berkeley (4/8) 2012 Austin (11/9,11/12)
Temple of the Dog - 2016 Upper Darby
Caffe Trieste in North Shore is a cool spot. Bunch of the Beats hung out there. Coppola penned most of The Godfather there, too. If you are into garlic -- and I mean a lot of garlic -- The Stinking Rose would be your restaurant. Travel a bit south into Big Sur. Beautiful area.
As for Portland, the Pearl District is cool. Throw a rock in any direction and you'll hit a cool restaurant/bar/café. Great place to hipster watch. Some of the best eatin' is found at the food trucks. There are a number of "pods" in Downtown.
Also, if you happen to stop in Cannon Beach, OR, do yourself a favor and eat at Pizza A'Fetta. Delicious!
Oregon:
Bend
Klamath Falls
California:
Alturas
Susanville
Oroville
and, sorry to say, you'd not get many odd looks in my town, Placerville.